Dr Bryson Hawkins

Dr Bryson Hawkins

Lecturer

Bachelor of Pharmacy, Hons (I) (The University of Sydney)

Doctor of Philosophy (The University of Sydney); Entitled: Experimental and Theoretical Charge Density Studies to Explore the Physical and Chemical Properties of Molecules

Medicine & Health
School of Health Sciences

Dr Bryson Hawkins is a Lecturer in Pharmaceutical Sciences in the School of Health Sciences (Pharmacy), Faculty of Medicine and Health, University of New South Wales.

Bryson, completed B.Pharm (Hons I) in 2017 at Sydney Pharmacy School (SPS), University of Sydney, before joining Royal North Shore Hospital (RNSH) as clinical pharmacist. In 2019 he returned to SPS for his doctoral training graduating in 2022. His PhD work employed high-resolution X-Ray Crystallography to investigate the weak interactions within polymorphic pharmaceutics, including co-crystals, aiming to decode the interaction networks to improve the physical and chemical properties of drug molecules.

Following his PhD, Bryson held an education-focused lecturer position in the SPS, before joining Prof. Kim Lewis' Antimicrobial Discovery Center (ADC), Northeastern University, Boston USA. As a Research Scientist at the ADC, Bryson worked in the drug discovery arm of the ADC focusing on the discovery and enhancement of antibiotics, like darobactin, which can treat infections caused by Gram-negative ESKAPE pathogens like Pseudomonas aeruginosa. To do this he used many techniques to cover the vast amount of chemical space seen in natural products. These included in silico modelling, genome mining, high-throughput screening, and targeted genetic modification of natural product producers.

Location
Health Translational Hub, Level 6 North UNSW SYDNEY 2052
  • Book Chapters | 2021
    Lai F; Hawkins BA; Cruz E; Hanrahan JR; Groundwater PW; Hibbs DE, 2021, 'Drug Targets for Biologics', in Biologics Biosimilars and Biobetters an Introduction for Pharmacists Physicians and Other Health Practitioners, pp. 195 - 212, http://dx.doi.org/10.1002/9781119564690.ch5
  • Journal articles | 2025
    Gilchrist AM; McNaughton DA; Fares M; Wu X; Hawkins BA; Butler SJ; Hibbs DE; Gale PA, 2025, 'Tetralactam-based anion transporters', Chem, 11, http://dx.doi.org/10.1016/j.chempr.2024.09.028
    Journal articles | 2025
    Hawkins BA; Adair LD; Ryder WG; Du JJ; Najib E; New EJ; Gale PA; Platts JA; Groundwater PW; Hibbs DE, 2025, 'Influence of Halogen Substituents on the Photophysical Properties of 7-Hydroxycoumarin: Insights from Experimental and Theoretical Studies', Chemphyschem, 26, http://dx.doi.org/10.1002/cphc.202400812
    Journal articles | 2025
    Pitt N; Morrissette M; Gates MF; Bargabos R; Krumpoch M; Hawkins B; Lewis K, 2025, 'Bacterial membrane vesicles restore gut anaerobiosis', Npj Biofilms and Microbiomes, 11, http://dx.doi.org/10.1038/s41522-025-00676-z
    Journal articles | 2025
    Ryder WG; Levina A; Graziotto ME; Hawkins BA; Hibbs DE; New EJ; Gale PA, 2025, 'Subcellular targeted anion transporters', Chem, 11, http://dx.doi.org/10.1016/j.chempr.2024.07.009
    Journal articles | 2025
    Son S; Shahsavari N; Privalsky T; Hawkins BA; Lee MH; Pitt N; Iinishi A; Taher R; Gupta N; Shankar CS; Patel J; Lewis K, 2025, 'A sulfur-containing nucleoside antibiotic from Photorhabdus', Mbio, 16, pp. 1 - 18, http://dx.doi.org/10.1128/mbio.02164-25
    Journal articles | 2024
    Bargabos R; Iinishi A; Hawkins B; Privalsky T; Pitt N; Son S; Corsetti R; Gates MF; Miller RD; Lewis K, 2024, 'Small molecule produced by Photorhabdus interferes with ubiquinone biosynthesis in Gram-negative bacteria', Mbio, 15, http://dx.doi.org/10.1128/mbio.01167-24
    Journal articles | 2024
    Nguyen TA; Chen RH; Hawkins BA; Hibbs DE; Kim HY; Wheate NJ; Groundwater PW; Stocker SL; Alffenaar JWC, 2024, 'Can we Predict Drug Excretion into Saliva? A Systematic Review and Analysis of Physicochemical Properties', Clinical Pharmacokinetics, 63, pp. 1067 - 1087, http://dx.doi.org/10.1007/s40262-024-01398-9
    Journal articles | 2024
    Song NK; Musa H; Soriano M; Batger M; Hawkins B; Ramzan I; Hibbs DE; Ong J, 2024, 'Safety and efficacy comparisons of intravenous trastuzumab biosimilars to the reference product medicine in treatment-naïve and switch-over patients with breast cancer: a systematic and meta-analysis', Journal of Pharmacy Practice and Research, 54, pp. 1 - 32, http://dx.doi.org/10.1002/jppr.1882
    Journal articles | 2023
    Chang Y; Hawkins BA; Du JJ; Groundwater PW; Hibbs DE; Lai F, 2023, 'A Guide to In Silico Drug Design', Pharmaceutics, 15, http://dx.doi.org/10.3390/pharmaceutics15010049
    Journal articles | 2023
    Gilchrist AM; Wu X; Hawkins BA; Hibbs DE; Gale PA, 2023, 'Fluorinated tetrapodal anion transporters', Iscience, 26, http://dx.doi.org/10.1016/j.isci.2023.105988
    Journal articles | 2022
    El-Khoury C; Mansour E; Yuliandra Y; Lai F; Hawkins BA; Du JJ; Sundberg EJ; Sluis-Cremer N; Hibbs DE; Groundwater PW, 2022, 'The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification', Rsc Medicinal Chemistry, 13, pp. 1276 - 1299, http://dx.doi.org/10.1039/d2md00263a
    Journal articles | 2022
    Hawkins BA; Du JJ; Lai F; Stanton SA; Williams PA; Groundwater PW; Platts JA; Overgaard J; Hibbs DE, 2022, 'An experimental and theoretical charge density study of theophylline and malonic acid cocrystallization', Rsc Advances, 12, pp. 15670 - 15684, http://dx.doi.org/10.1039/d1ra08389a
    Journal articles | 2022
    Hawkins BA; Najib E; Du JJ; Lai F; Platts JA; Groundwater PW; Hibbs DE, 2022, 'Exploring the excited-state charge transfer fluorescence profile of 7-hydroxycoumarin and 2-methylimidazole - a combined X-ray diffraction and theoretical approach', Physical Chemistry Chemical Physics, 24, pp. 13015 - 13025, http://dx.doi.org/10.1039/d2cp01235a
    Journal articles | 2022
    Lin HYJ; Battaje RR; Tan J; Doddareddy M; Dhaked HPS; Srivastava S; Hawkins BA; Al-Shdifat LMH; Hibbs DE; Panda D; Groundwater PW, 2022, 'Discovery of 2′,6-Bis(4-hydroxybenzyl)-2-acetylcyclohexanone, a Novel FtsZ Inhibitor', Molecules, 27, http://dx.doi.org/10.3390/molecules27206993
    Journal articles | 2022
    Song NK; Musa H; Soriano M; Batger M; Hawkins B; Ramzan I; Hibbs DE; Ong JA, 2022, 'Safety and efficacy comparisons of rituximab biosimilars to the reference product in patients with cancer: a systematic meta-analysis review', Journal of Pharmacy Practice and Research, 52, pp. 331 - 355, http://dx.doi.org/10.1002/jppr.1827
    Journal articles | 2021
    Du JJ; Stanton SA; Fakih S; Hawkins BA; Williams PA; Groundwater PW; Overgaard J; Platts JA; Hibbs DE, 2021, 'Exploring the Solubility of the Carbamazepine-Saccharin Cocrystal: A Charge Density Study', Crystal Growth and Design, 21, pp. 4259 - 4275, http://dx.doi.org/10.1021/acs.cgd.8b01111
    Journal articles | 2021
    Hawkins BA; Han J; Du JJ; Lai F; Stanton SA; Divakarla SS; Groundwater PW; Platts JA; Hibbs DE, 2021, 'Analyzing Hydration Differences in Cocrystal Polymorphs: High-Resolution X-ray Investigation of Caffeine-Glutaric Acid Cocrystals', Crystal Growth and Design, 21, pp. 4456 - 4467, http://dx.doi.org/10.1021/acs.cgd.1c00358
    Journal articles | 2021
    Mcnaughton DA; To TYT; Hawkins BA; Hibbs DE; Gale PA, 2021, 'Delivering anion transporters to lipid bilayers in water', Organic and Biomolecular Chemistry, 19, pp. 9624 - 9628, http://dx.doi.org/10.1039/d1ob02041b
    Journal articles | 2021
    Stanton SA; Du JJ; Lai F; Stanton G; Hawkins BA; Ong JA; Groundwater PW; Platts JA; Hibbs DE, 2021, 'Understanding Hygroscopicity of Theophylline via a Novel Cocrystal Polymorph: A Charge Density Study', Journal of Physical Chemistry A, 125, pp. 9736 - 9756, http://dx.doi.org/10.1021/acs.jpca.0c09536
    Journal articles | 2017
    Akkoç S; Kayser V; İlhan İÖ; Hibbs DE; Gök Y; Williams PA; Hawkins B; Lai F, 2017, 'New compounds based on a benzimidazole nucleus: synthesis, characterization and cytotoxic activity against breast and colon cancer cell lines', Journal of Organometallic Chemistry, 839, pp. 98 - 107, http://dx.doi.org/10.1016/j.jorganchem.2017.03.037
    Journal articles | 2016
    Panda D; Bhattacharya D; Gao QH; Oza PM; Lin HYJ; Hawkins B; Hibbs DE; Groundwater PW, 2016, 'Identification of agents targeting FtsZ assembly', Future Medicinal Chemistry, 8, pp. 1111 - 1132, http://dx.doi.org/10.4155/fmc-2016-0041

High Performer PhD Stipend, The University of Sydney, Australia (2020-2022)

 

Dr Hawkins is a molecular biologist/natural products chemist who uses many tools for untapping the chemical space of natural products. His research interests include ultra-high throughput screening for drug discovery and development. 

He uses a wide arsenal of approaches including microbiology, molecular biology, fluorescence-activated droplet sorting, chemical purification and charactersation, and,  in silico / computational chemistry.