Associate Professor Sze-Yuan Ooi
Bachelor of Medicine & Bachelor of Surgery (Hons) University of Queensland 1997
Fellow of the Royal Australasian College of Physicians July 2007
Doctor of Medicine (MD) with commendation 2008 University of Leeds, UK
Sze-Yuan is a clinician researcher with extensive clinical experience and expertise in the fields of coronary intervention and cardiac device implantation, including novel implantable cardiac device and remote monitoring technologies. He is a Senior Staff Specialist at the Prince of Wales Hospital and is the current Director of the Coronary Care Unit. Prof Sze-Yuan Ooi obtained his Bachelor degree in Medicine and Surgery with Honours from the University of Queensland in 1997. He is a Fellow of the Australasian College of Physicians (FRACP) and the Cardiac Society of Australia and New Zealand (FCSANZ). Sze-Yuan held the position of Research Fellow in Cardiology at the Institute for Cardiovascular Research in Leeds, England from 2003 to 2005. He was awarded a Doctorate in Medicine with Commendation through the University of Leeds in 2008 for his thesis, “The role of cytokines in the pathogenesis of the acute coronary syndrome”.
His research interests include the pathogenesis of coronary atherosclerosis and the role of inflammation, coronary physiology, novel assessments of and modulation of the coronary microcirculation, new device technology and telehealth. Sze-Yuan has been awarded over $25M in research funding over the last 5 years.
- Publications
- Media
- Grants
- Awards
- Research Activities
- Engagement
- Teaching and Supervision
MRFF Cardiovascular Health Mission: Intelligent Dashboard for Heart Failure (ID-HF) to Improve Uptake of Optimal Heart Failure Care. Yu $3.9M (CIB) 2025
NHMRC TRC: Improving Physical Health of People with a Mental Illness. No-one left behind - Integrated Physical Health Care for People living with Severe Mental Illness. AI $2.997M (AI) 2022
NHMRC Partnership Projects. Integration of Cloud Based Artificial Intelligence Assisted Medical Image and Clinical Data Analysis into Workflows for Regional Stroke Patients (Cloud AI Stroke). Butcher $1.48M (CID) 2022
MRFF Data Infrastructure Grant. Next-generation clinical registries: common data models, AI & cloud compute. Jorm. $2.645M (CIC) 2022
HF Vanguard. Immersive technology to drive 4D transcatheter aortic valve replacement. Beier. $150k (CIC) 2022
NHMRC Ideas Grant. Opening the pathway to large data-driven patient-specific diagnostics using novel coronary angiogram analysis. Beier. $459K (CIB) 2021
NHMRC Ideas Grant. A novel, dual-targeted therapeutic approach for preventing accelerated atherosclerosis in type 2 diabetes. Rye $1.56M (AI) 2021
Heart Foundation Vanguard Grant. Biodegradable Nanoparticles as a Novel Clinically Viable Therapeutic Approach for the Treatment of Cardiovascular Disease. Thomas (CID) 2021
ARC Research Hub for Connected Sensors for Health. $5M (PI) 2021
MRFF CV Mission 2021. Development of novel, clinically viable strategies for reducing cardiac damage and preventing future events in MI survivors by targeting inflammation. $2.8M (CII) 2021
MRFF CV Mission 2021. Deep learning to predict and prevent secondary cardiovascular events $650k (CIC) 2021
SPHERE Cardiac & Vascular Heath CAG Seed Grant. Beier $30k (AI) 2021
SPHERE Cardiac & Vascular Heath CAG Seed Grant. Campaign $30k (AI) 2021
SPHERE Cardiac & Vascular Heath CAG Seed Grant. Hsu $30k (AI) 2021
UNSW CVMM Big Ideas Grant Cardiovascular Analytics and Innovation $150k (AI) 2021
UNSW CVMM Networking Grant. Arnold. $30k (AI) 2021
MRFF CV Mission TCC-Stroke 2020 $1.7M (CIB)
TRGS TCC-Cardiac Study 2020 $1.98M (CIA)
Australian Student’s Scholarship 1991
A.J. Mason Scholarship 1992 Brisbane Grammar School
University of Queensland Research Scholarship 1993 & 1994
Wilcken-McCredie Travelling Fellowship 2002 Prince of Wales Hospital
Stanley Taylor Foundation Research Grant 2003
Sze-Yuan holds a Conjoint Professor position with UNSW with a close association with the Tyree Foundation Institute of Health Engineering UNSW Sydney. I have been involved in many industry-driven studies involving novel stent and cardiac device technologies. He was the global Principal Investigator for the BioMonitor-2 first-in-human study of a novel implantable cardiac monitor, presenting the study findings at CardioStim, an International electrophysiology and devices meeting in 2016. He was an invited speaker on the topic of implantable loop recorders and member of faculty at the 2017 US Heart Rhythm Society meeting.
Sze-Yuan has co-designed, validated and implemented a smartphone application-based model of care, in collaboration with Prof Nigel Lovell, Graduate School of Biomedical Engineering UNSW. A pilot study assessing this system, TeleClinical Care (TCC) was completed in 2020. In conjunction with (co-CIA) Prof Lovell, he was awarded $1.89M in funding from the NSW Ministry of Health to conduct a large randomised controlled trial of TCC across multiple sites in New South Wales. He (CIB) was also awarded a $1.7M MRFF Cardiovascular grant to conduct a randomised controlled trial of an iterative version of this model of care for stroke patients (TCC-Stroke). Sze-Yuan led the co-design of a remote monitoring solution for COVID-19 patients isolating in the community (TCC-COVID). This system was implemented across the South Eastern Sydney Local Health District (SESLHD) during the COVID-19 pandemic, monitoring over 9,000 patients. In 2023, in partnership with Prof Lovell, we formed a startup company, Apostele, that supports this and other planned works that form the centrepiece of the Remote Patient Monitoring service in the Randwick Precinct redevelopment which delivers virtual care to multiple patient cohorts across the SESLHD community. Sze-Yuan was a named Partner Investigator on the ARC Hub for Connected sensors for Health ($5M, Chun Wang). He was invited to co-author an American Heart Association commissioned scientific statement on Telehealth and Health Equity in older adults with heart failure. Sze-Yuan has been invited to present this work at numerous meetings including the Australian Academy of Technological Sciences & Engineering (ATSE) 2022 seminar, the 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2023), the St Vincent’s Hospital Research Symposium 2021, the Pen CS 2021 National Primary Healthcare Network Conference, the National Cardiology Heads of Department meeting 2023 and as the keynote speaker at the 2024 Austrian D-Health conference.
Sze-Yuan is the lead clinician and data custodian for the Cardiac Analytics and Innovation (CardiacAI) project. In collaboration with the Centre for Big Data Research in Health UNSW Sydney, the CardiacAI group has developed and is currently piloting systems that allow for the automated collection of EMR data for cardiac patients upon which data-analytics and machine learning algorithms may be applied to improve patient care. The CardiacAI data repository houses over 8 years of retrospective EMR data as well as a nightly prospective data extract for all cardiac patients across SESLHD and the Illawarra Shoalhaven LHD (ISLHD). The CardiacAI group has been awarded 2 MRFF Cardiovascular Mission grants, an MRFF Research Data Infrastructure Grant and a UNSW CVMM Big Ideas grant (total funding >$7M) to expand the data repository to include stroke patients, add data from 2 additional Local Health Districts in New South Wales and build machine-learning algorithms to drive clinical decision support tools. I have been invited to present this work at numerous meetings including the NSW Cardiovascular Research Network 2022 workshop, the 2022 Australasian Institute of Digital Health Digital Summit, the 2023 Australian Cardiovascular Alliance Data Dashboard workshop, the 2023 Combined NSW Research Translation Centres Cardiovascular Symposium and the 2023 Sydney Cardiovascular Symposium.
My Research Supervision
Sze-Yuan has supervised 3 PhD students, 1 Masters of Health in Health Data Science and 2 Masters in Medicine student to completion, and is currently supervising 1 PhD student and 1 Masters in Medicine Research students.